Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation

Background: The clinical characteristics of human metapneumovirus (hMPV)-associated lower respiratory tract infection (LRTI) after allogeneic hematopoietic stem cell transplantation (HSCT) is not well described. We describe the clinical course in eight HSCT recipients suffering from hMPV infection. Methods: We prospectively included all patients with hMPV-associated LRTI after allogeneic HSCT during a period of 1year. hMPV was diagnosed by multiplex polymerase chain reaction (PCR) from bronchoalveolar lavage (BAL). Results: Eight patients with hMPV-associated LRTI were identified from 93 BAL samples. Three of the eight patients had co-infections with other pathogens. The median age of the patients was 45years [interquartile range (IQR) 36.8-53.5], the median time posttransplant was 473days (IQR 251-1,165), 5/8 patients had chronic graft-versus-host disease (cGvHD), and 6/8 patients received immunosuppression. Chest computed tomography (CT) scanning showed a ground-glass pattern in 7/8 patients. Seven of eight patients required hospitalization due to severe symptoms and hypoxemia. All were treated with intravenous immunoglobulin (IVIG), which was combined with oral ribavirin in six patients. The mortality rate was 12.5% (1/8). Conclusions: hMPV-associated LRTI in allogeneic HSCT recipients are not uncommon and present with unspecific respiratory symptoms, ground-glass pattern in CT scanning, and co-infectio

The future of Cybersecurity in Italy: Strategic focus area

This volume has been created as a continuation of the previous one, with the aim of outlining a set of focus areas and actions that the Italian Nation research community considers essential. The book touches many aspects of cyber security, ranging from the definition of the infrastructure and controls needed to organize cyberdefence to the actions and technologies to be developed to be better protected, from the identification of the main technologies to be defended to the proposal of a set of horizontal actions for training, awareness raising, and risk management

METODO ED IMPIANTO PER IL TRATTAMENTO DI RIFIUTI CONTENENTI AMIANTO

Metodo per la distruzione dell’amianto presente in rifiuti contenenti amianto (RCA) a matrice prevalentemente organica, il quale comprende, in accordo con la rivendicazione 1, le fasi: di preparazione del rifiuto contenente amianto; di preparazione di una fase acquosa in condizioni supercritiche; di reazione per un tempo t in opportuno reattore dell’amianto e della matrice prevalentemente organica del rifiuto contenente amianto con la fase acquosa a una pressione P e una temperatura T predeterminate in modo da mantenere la fase acquosa in condizioni supercritiche; di raffreddamento e condensazione della fase acquosa uscente dal reattore; di separazione di detta fase acquosa da eventuali prodotti solidi trascinati. Il metodo è caratterizzato dal fatto che la fase di preparazione della fase acquosa in condizioni supercritiche comprende un’ulteriore fase di aggiunta di almeno un composto ossidante in una concentrazione predeterminata C, che la pressione P è compresa tra 25 e 27 MPa e che la temperatura T è compresa tra 600°C e 650°C in modo da ottenere una contemporanea distruzione dell’amianto e del legante di natura organica

METHOD AND PLANT FOR TREATMENT OF ASBESTOS-CONTAINING WASTE MATERIALS IN SUPERCRITICAL WATER

Method for destroying asbestos in mainly organic matrix asbestos-containing waste (ACW), which comprises, according to claim 1 , the steps of: preparing the asbestos-containing waste; preparing a supercritical aqueous phase; allowing asbestos and the primarily organic matrix of the asbestos-containing waste to react with the aqueous phase for a time t in an appropriate reactor at predetermined pressure P and temperature T to maintain the aqueous phase in supercritical conditions; cooling and condensing the aqueous phase flowing out of the reactor; separating said aqueous phase from any entrained solid product therein. The method is characterized in that the step in which the supercritical aqueous phase is prepared comprises an additional step in which at least one oxidizing compound is added in a predetermined concentration C1 and in that the pressure P is in a range from 25 to 27 MPa and the temperature T is in a range from 6000C to 650°C, for asbestos and the organic binder to be simultaneously destroyed

Method and plant for treatment of asbestos-containing waste materials

The present invention is generally applicable to waste disposal and treatment and particularly relates to a method and plant for treatment of mainly organic matrix asbestos-containing waste, known as ACW